Leyton Orient have confirmed that “a number” of first-team players have tested positive for coronavirus.
The O’s are due to host Premier League Tottenham in the Carabao Cup on Tuesday but are in discussions with Public Health England about whether any further action needs to be taken.
The club said in a statement that the tests were carried out after Saturday’s 2-2 draw with Mansfield in League Two.
Their most recent opponents – Plymouth, Mansfield and Oldham – have been told.
“Leyton Orient’s priority is the health and wellbeing of its players and staff. Those who have tested positive will now strictly follow government self-isolation guidelines,” the O’s said.
“The Breyer Group Stadium and training ground facilities will be closed until further notice.”
It is understood that if Orient are unable to field a team, the game will be awarded to Spurs as there is not enough room in the schedule to rearrange the tie.
Tottenham have a more congested schedule than most because of their Europa League commitments, with their next game in that competition in Macedonia against Shkendija on Thursday.
Orient’s tie with Jose Mourinho’s men would have seen them potentially come up against striker Harry Kane, who paid to promote charities on the front of their shirts in May. The England captain made his professional debut during a loan spell with the O’s when he was 17.
The English Football League say they are “awaiting the outcome” of Orient’s discussions with Public Health England.
Plymouth, who were beaten by Orient in the previous round of the EFL Cup, and Mansfield say they will test their players and football staff as a result, adding that none of them currently have symptoms.